Product Description: chromatin assembly factor 1 subunit C, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0042393 | histone binding |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0031497 | chromatin assembly |
| Process | GO:0006334 | nucleosome assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.23 | 0.89 |
| Trophozoite | expressed | 1.09 | 0.47 |
| Schizont | expressed | 0.15 | 0.91 |
| Gametocyte | expressed | 0.87 | 0.60 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0110700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.157 | MFS: -3.013 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1011600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0203000)
Modification: Disrupted | RMgm-1671
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I238
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101102
Most Similar Human Ortholog: E9PC52
TM-align score: 0.91 | RMSD: 2.20
Seq Identity: 0.31 | Length: 402 / 446
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000102054 | RB binding protein 7, chromatin remodeling factor |
| ENSG00000162521 | RB binding protein 4, chromatin remodeling factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 1 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 190
Non-coding: 182 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 446 | Molecular Weight (kDa): 50.733
UniProt ID(s): Q8I238
PDB ID(s): None
Isoelectric Point: 4.73
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR022052 | Histone-binding protein RBBP4, N-terminal |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| PFam | PF12265 | Histone-binding protein RBBP4, N-terminal |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 32363442 | The multifaceted histone chaperone RbAp46/48 in Plasmodium falciparum: structuralinsights, production, and characterization. | Kaushik M, Nehra A, ..., Gill R | 10.1007/s00436-020-06669-5 |