Product Description: transcription initiation factor TFIIB, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0097550 | transcription preinitiation complex |
| Component | GO:0005667 | transcription regulator complex |
| Function | GO:0000993 | RNA polymerase II complex binding |
| Function | GO:0001139 | RNA polymerase II complex recruiting activity |
| Function | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| Function | GO:0017025 | TBP-class protein binding |
| Function | GO:0008134 | transcription factor binding |
| Process | GO:0006352 | DNA-templated transcription, initiation |
| Process | GO:0051123 | RNA polymerase II preinitiation complex assembly |
| Process | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| Process | GO:0001174 | transcriptional start site selection at RNA polymerase II promoter |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.55 | 0.73 |
| Trophozoite | expressed | 0.42 | 0.76 |
| Schizont | expressed | 0.23 | 0.87 |
| Gametocyte | expressed | 0.60 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0110800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.199 | MFS: -3.59 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0202900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0202900)
Modification: Disrupted | RMgm-1670
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I237
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101024
Most Similar Human Ortholog: B1APE1
TM-align score: 0.80 | RMSD: 2.81
Seq Identity: 0.25 | Length: 209 / 367
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000137947 | general transcription factor IIB |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 20 | 12 | 13 |
| disruptive | 3 | 9 | 5 | 18 |
| missense | 3 | 9 | 4 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 39 | 12 | 20 |
| disruptive | 7 | 18 | 27 | 71 |
| missense | 6 | 13 | 19 | 48 |
PlasmoDB Total SNPs: 166
Non-coding: 150 | Synonymous: 13 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 367 | Molecular Weight (kDa): 42.002
UniProt ID(s): Q8I237
PDB ID(s): None
Isoelectric Point: 9.72
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000812 | Transcription factor TFIIB |
| InterPro | IPR013137 | Zinc finger, TFIIB-type |
| InterPro | IPR036915 | Cyclin-like superfamily |
| PFam | PF08271 | Zinc finger, TFIIB-type |
| Superfamily | SSF47954 | Cyclin-like superfamily |
| Superfamily | SSF57783 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15950069 | Model of the TBP-TFIIB complex from Plasmodium falciparum: interface analysis andperspectives as a new target for antimalarial design. | Buendia-Orozco J, Guerrero A, Pastor N | 10.1016/j.arcmed.2005.03.020 |