Product Description: adenylate kinase-like protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.4.3 (Adenylate kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0005524 | ATP binding |
| Function | GO:0004017 | adenylate kinase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.14 | 0.93 |
| Trophozoite | possibly expressed | 0.27 | 0.84 |
| Schizont | possibly expressed | 0.03 | 0.98 |
| Gametocyte | possibly expressed | 0.09 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0110900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.014 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I236
"Best" AlphaFill ligand hit: DAT (dadp, Local RMSD=0.48) with 3IIM (Global RMSD=2.71)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.4.3 | adenylate kinase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101453
Most Similar Human Ortholog: Q9Y3D8
TM-align score: 0.92 | RMSD: 1.44
Seq Identity: 0.35 | Length: 167 / 186
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000085231 | adenylate kinase 6 |
| ENSG00000279247 | adenylate kinase 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 6 | 5 | 4 |
| disruptive | 1 | 17 | 5 | 23 |
| missense | 1 | 17 | 5 | 18 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 18 | 2 | 10 |
| disruptive | 2 | 39 | 16 | 64 |
| missense | 1 | 33 | 14 | 32 |
PlasmoDB Total SNPs: 59
Non-coding: 55 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 186 | Molecular Weight (kDa): 22.173
UniProt ID(s): Q8I236
PDB ID(s): None
Isoelectric Point: 4.71
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR020618 | Adenylate kinase isoenzyme 6 |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF13238 | N/A |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 22819813 | Subcellular localization of adenylate kinases in Plasmodium falciparum. | Ma J, Rahlfs S, ..., Becker K | 10.1016/j.febslet.2012.07.013 |