Product Description: kinesin-8B, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005881 | cytoplasmic microtubule |
| Component | GO:0005871 | kinesin complex |
| Component | GO:0005874 | microtubule |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0008017 | microtubule binding |
| Function | GO:0003777 | microtubule motor activity |
| Function | GO:0008574 | plus-end-directed microtubule motor activity |
| Process | GO:0035082 | axoneme assembly |
| Process | GO:0060271 | cilium assembly |
| Process | GO:0007018 | microtubule-based movement |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.98 |
| Trophozoite | not expressed | 0.30 | 0.81 |
| Schizont | possibly expressed | 0.57 | 0.66 |
| Gametocyte | possibly expressed | 0.90 | 0.56 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0111000
Resistome Missense Mutations: M1039L
Resistome Compounds with Missense Mutations: OSM-S-106
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.224 | #Insertions: 5
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0805900)
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0202700)
Modification: Tagged | RMgm-5365
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I235
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.03) with 3K3B (Global RMSD=4.72)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q8NI77 | Kinesin-like protein KIF18A | OrthoDB | US11236069, Example 1US11236069, Example 1-1US11236069, Example 1-2US11236069, Example 1-3... |
Ortholog Group (OrthoMCL): OG6_100835
Most Similar Human Ortholog: F8VW50
TM-align score: 0.55 | RMSD: 3.97
Seq Identity: 0.45 | Length: 375 / 1664
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000121621 | kinesin family member 18A |
| ENSG00000186185 | kinesin family member 18B |
| ENSG00000196169 | kinesin family member 19 |
Protein Length: 1664 | Molecular Weight (kDa): 191.873
UniProt ID(s): Q8I235
PDB ID(s): None
Isoelectric Point: 6.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001752 | Kinesin motor domain |
| InterPro | IPR019821 | Kinesin motor domain, conserved site |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR027640 | Kinesin-like protein |
| PFam | PF00225 | Kinesin motor domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 67 | 40 | 80 |
| disruptive | 64 | 159 | 86 | 237 |
| missense | 32 | 135 | 68 | 190 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 30 | 146 | 46 | 82 |
| disruptive | 99 | 319 | 174 | 322 |
| missense | 57 | 249 | 131 | 234 |
PlasmoDB Total SNPs: 525
Non-coding: 339 | Synonymous: 102 | Nonsynonymous: 84 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 31409625 | Kinesin-8 B controls basal body function and flagellum formation and is key tomalaria transmission | Zeeshan M, Ferguson DJ, ..., Tewari R | 10.26508/lsa.201900488 |