PF3D7_0111400 (GEXP19)

Genome location: Pf3D7_01_v3:436,179..439,368(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	not expressed	0.79	0.58
Schizont	possibly expressed	0.26	0.84
Gametocyte	not expressed	0.62	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0111400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.209 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: B9ZSI9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532753

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	24	21	36
disruptive	22	78	40	97
missense	7	50	33	71

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	57	24	40
disruptive	49	175	86	198
missense	14	113	64	132

PlasmoDB Total SNPs: 114

Non-coding: 64 | Synonymous: 35 | Nonsynonymous: 13 | Stop Codon: 2

Protein Information

Protein Length: 718 | Molecular Weight (kDa): 85.036

UniProt ID(s): B9ZSI9

PDB ID(s): None

Isoelectric Point: 9.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A