Product Description: UMP-CMP kinase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 2.7.4.14 (UMP/CMP kinase);2.7.4.3 (Adenylate kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0033862 | UMP kinase activity |
| Function | GO:0004127 | cytidylate kinase activity |
| Function | GO:0004550 | nucleoside diphosphate kinase activity |
| Function | GO:0004849 | uridine kinase activity |
| Process | GO:0046705 | CDP biosynthetic process |
| Process | GO:0006225 | UDP biosynthetic process |
| Process | GO:0006165 | nucleoside diphosphate phosphorylation |
| Process | GO:0006163 | purine nucleotide metabolic process |
| Process | GO:0006221 | pyrimidine nucleotide biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.10 | 0.95 |
| Trophozoite | expressed | 0.73 | 0.59 |
| Schizont | expressed | 0.86 | 0.53 |
| Gametocyte | not expressed | 0.31 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0111500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.031 | #Insertions: 0
PlasmoGEM Phenotype: Insufficient data (Pb ortholog: PBANKA_0202300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I231
"Best" AlphaFill ligand hit: AP5 (bis(adenosine)-5'-pentaphosphate, Local RMSD=0.16) with 5YCD (Global RMSD=3.61)
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100591
Most Similar Human Ortholog: P30085
TM-align score: 0.96 | RMSD: 1.10
Seq Identity: 0.44 | Length: 195 / 371
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000106992 | adenylate kinase 1 |
| ENSG00000162368 | cytidine/uridine monophosphate kinase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 15 | 5 | 15 |
| disruptive | 8 | 31 | 14 | 29 |
| missense | 8 | 26 | 13 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 21 | 17 | 15 |
| disruptive | 15 | 71 | 34 | 90 |
| missense | 10 | 51 | 26 | 55 |
PlasmoDB Total SNPs: 143
Non-coding: 122 | Synonymous: 12 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 371 | Molecular Weight (kDa): 44.245
UniProt ID(s): Q8I231
PDB ID(s): None
Isoelectric Point: 8.73
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000850 | Adenylate kinase/UMP-CMP kinase |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR033690 | Adenylate kinase, conserved site |
| PFam | PF00406 | N/A |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |