PF3D7_0111600

Genome location: Pf3D7_01_v3:442,380..443,473(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	possibly expressed	0.11	0.92
Schizont	not expressed	0.07	0.96
Gametocyte	not expressed	0.39	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0111600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.435 | MFS: -3.525 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I230

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532403

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	5	3	12
disruptive	3	16	10	26
missense	3	16	9	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	15	6	12
disruptive	8	49	24	77
missense	5	40	20	53

PlasmoDB Total SNPs: 45

Non-coding: 41 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 248 | Molecular Weight (kDa): 30.584

UniProt ID(s): Q8I230

PDB ID(s): None

Isoelectric Point: 9.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A