Product Description: eukaryotic translation initiation factor 4E, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016281 | eukaryotic translation initiation factor 4F complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0000340 | RNA 7-methylguanosine cap binding |
| Function | GO:0003743 | translation initiation factor activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.13 | 0.94 |
| Trophozoite | expressed | 0.59 | 0.66 |
| Schizont | expressed | 0.09 | 0.95 |
| Gametocyte | expressed | 0.38 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0111800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 4 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.607 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: B9ZSJ0
"Best" AlphaFill ligand hit: MGT (7n-methyl-8-hydroguanosine-5'-triphosphate, Local RMSD=0.42) with 5ZK7 (Global RMSD=3.01)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P06730 | Eukaryotic translation initiation factor 4E | OrthoDB | US9073881, 109US9073881, 2US9073881, 3US9073881, 4... | |
| P29338 | Eukaryotic translation initiation factor 4E | Oryctolagus cuniculus | OrthoDB | CHEMBL3604542CHEMBL3604543CHEMBL1094973CHEMBL3604536... |
Ortholog Group (OrthoMCL): OG6_101698
Most Similar Human Ortholog: C9JEL3
TM-align score: 0.73 | RMSD: 2.35
Seq Identity: 0.23 | Length: 173 / 620
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000135930 | eukaryotic translation initiation factor 4E family member 2 |
Protein Length: 620 | Molecular Weight (kDa): 73.031
UniProt ID(s): B9ZSJ0
PDB ID(s): None
Isoelectric Point: 9.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001040 | Translation Initiation factor eIF- 4e |
| InterPro | IPR023398 | Translation Initiation factor eIF- 4e-like |
| PFam | PF01652 | Translation Initiation factor eIF- 4e |
| Superfamily | SSF55418 | Translation Initiation factor eIF- 4e-like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 13 | 9 | 17 |
| disruptive | 11 | 48 | 30 | 86 |
| missense | 10 | 40 | 26 | 65 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 23 | 24 | 34 |
| disruptive | 30 | 166 | 70 | 206 |
| missense | 17 | 102 | 47 | 103 |
PlasmoDB Total SNPs: 366
Non-coding: 317 | Synonymous: 35 | Nonsynonymous: 14 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |