Product Description: mitochondrial distribution and morphology protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.14 | 0.90 |
| Schizont | expressed | 0.10 | 0.92 |
| Gametocyte | not expressed | 0.09 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0111900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.121 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I227
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104453
Most Similar Human Ortholog: O43715
TM-align score: 0.57 | RMSD: 2.27
Seq Identity: 0.32 | Length: 57 / 81
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000170855 | TP53 regulated inhibitor of apoptosis 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 3 | 2 | 4 |
| disruptive | 1 | 1 | 2 | 3 |
| missense | 1 | 1 | 2 | 2 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 4 | 3 | 6 |
| disruptive | 2 | 9 | 8 | 21 |
| missense | 1 | 6 | 6 | 14 |
PlasmoDB Total SNPs: 20
Non-coding: 20 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 81 | Molecular Weight (kDa): 9.582
UniProt ID(s): Q8I227
PDB ID(s): None
Isoelectric Point: 7.08
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007918 | Mitochondrial distribution/morphology family 35/apoptosis |
| PFam | PF05254 | Mitochondrial distribution/morphology family 35/apoptosis |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |