Product Description: PIMMS1 protein
SignalP Peptide: MKLLNNRFVVLCPIIILFFFLNSVVLG
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071944 | cell periphery |
| Component | GO:0005737 | cytoplasm |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.01 | 1.00 |
| Schizont | not expressed | 0.01 | 1.00 |
| Gametocyte | not expressed | 0.01 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0112100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.754 | MFS: -2.189 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0201700)
Modification: Tagged | RMgm-5000
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9U0N5
"Best" AlphaFill ligand hit: DEQ (dequadin, Local RMSD=0.59) with 3BR1 (Global RMSD=14.92)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 2 | 4 |
| disruptive | 0 | 4 | 3 | 11 |
| missense | 0 | 4 | 2 | 8 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 2 | 2 | 7 |
| disruptive | 2 | 11 | 8 | 19 |
| missense | 1 | 10 | 8 | 12 |
PlasmoDB Total SNPs: 4
Non-coding: 0 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 163 | Molecular Weight (kDa): 19.242
UniProt ID(s): Q9U0N5
PDB ID(s): None
Isoelectric Point: 4.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 33791240 | Identification of Three Novel Plasmodium Factors Involved in Ookinete to OocystDevelopmental Transition. | Ukegbu CV, Christophides GK, Vlachou D | 10.3389/fcimb.2021.634273 |