Product Description: multidrug resistance-associated protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 11
EC Numbers: 3.6.3.44 (Transferred entry: 7.6.2.2)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005887 | integral component of plasma membrane |
| Component | GO:0016020 | membrane |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0042626 | ATPase-coupled transmembrane transporter activity |
| Function | GO:0043295 | glutathione binding |
| Process | GO:0042493 | response to drug |
| Process | GO:0009410 | response to xenobiotic stimulus |
| Process | GO:0055085 | transmembrane transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.24 | 0.89 |
| Trophozoite | possibly expressed | 1.74 | 0.27 |
| Schizont | possibly expressed | 0.23 | 0.87 |
| Gametocyte | not expressed | 0.09 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0112200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.001 | #Insertions: 12
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1443800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9U0N4
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.02) with 6GKD (Global RMSD=2.34)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.3.44 | xenobiotic-transporting ATPase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100026
Most Similar Human Ortholog: Q96J65
TM-align score: 0.83 | RMSD: 4.10
Seq Identity: 0.19 | Length: 1230 / 1822
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000006071 | ATP binding cassette subfamily C member 8 |
| ENSG00000023839 | ATP binding cassette subfamily C member 2 |
| ENSG00000069431 | ATP binding cassette subfamily C member 9 |
| ENSG00000091262 | ATP binding cassette subfamily C member 6 |
| ENSG00000103222 | ATP binding cassette subfamily C member 1 |
| ENSG00000108846 | ATP binding cassette subfamily C member 3 |
| ENSG00000114770 | ATP binding cassette subfamily C member 5 |
| ENSG00000121270 | ATP binding cassette subfamily C member 11 |
| ENSG00000124574 | ATP binding cassette subfamily C member 10 |
| ENSG00000125257 | ATP binding cassette subfamily C member 4 |
| ENSG00000140798 | ATP binding cassette subfamily C member 12 |
| ENSG00000275331 | ATP binding cassette subfamily C member 6 |
| ENSG00000278183 | ATP binding cassette subfamily C member 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 18 | 20 | 24 |
| disruptive | 22 | 44 | 24 | 84 |
| missense | 20 | 38 | 21 | 75 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 33 | 23 | 38 |
| disruptive | 34 | 112 | 62 | 198 |
| missense | 23 | 84 | 51 | 130 |
PlasmoDB Total SNPs: 177
Non-coding: 124 | Synonymous: 34 | Nonsynonymous: 19 | Stop Codon: 0
Protein Length: 1822 | Molecular Weight (kDa): 214.441
UniProt ID(s): A0A076PXU8, A0A076Q0J9, A0A076Q2S6, A0A076Q2T2, A0A076Q2X9, A0A076Q432, A0A076Q452, D0QEV0, D0QEV4, D0QF07, Q9U0N4
PDB ID(s): None
Isoelectric Point: 8.99
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003439 | ABC transporter-like |
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR011527 | ABC transporter type 1, transmembrane domain |
| InterPro | IPR017871 | ABC transporter, conserved site |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR030244 | Oligomycin resistance ATP-dependent permease Yor1 |
| InterPro | IPR036640 | ABC transporter type 1, transmembrane domain superfamily |
| PFam | PF00005 | ABC transporter-like |
| PFam | PF00664 | ABC transporter type 1, transmembrane domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF90123 | ABC transporter type 1, transmembrane domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15358235 | Plasmodium falciparum expresses a multidrug resistance-associated protein. | Klokouzas A, Tiffert T, ..., Hladky SB | 10.1016/j.bbrc.2004.06.135 |
| 19117944 | Disruption of a Plasmodium falciparum multidrug resistance-associated protein(PfMRP) alters its fitness and transport of antimalarial drugs and glutathione. | Raj DK, Mu J, ..., Su XZ | 10.1074/jbc.M806944200 |
| 20547801 | Absence of association between piperaquine in vitro responses and polymorphismsin the pfcrt, pfmdr1, pfmrp, and pfnhe genes in Plasmodium falciparum. | Briolant S, Henry M, ..., Pradines B | 10.1128/AAC.00183-10 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 38204967 | Structural and molecular characterization of lopinavir and ivermectin as breastcancer resistance protein (BCRP/ABCG2) inhibitors | Dutra JP, Scheiffer G, ..., Moure VR | 10.17179/excli2023-6427 |