About Gene List

PF3D7_0112800

Genome location: Pf3D7_01_v3:481,231..483,218(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp11), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020002 host cell plasma membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.07 0.96
Trophozoite not expressed 0.02 0.99
Schizont not expressed 0.01 0.99
Gametocyte possibly expressed 0.04 0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0112800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.559 | MFS: -2.078 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0N3

"Best" AlphaFill ligand hit: GM6 (gm6001, Local RMSD=0.76) with 1PWU (Global RMSD=25.18)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_158824

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 3 1 5
disruptive 5 9 6 21
missense 5 9 5 17

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 8 5 13
disruptive 9 21 22 52
missense 8 16 18 35

PlasmoDB Total SNPs: 98

Non-coding: 90 | Synonymous: 2 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 203 | Molecular Weight (kDa): 25.241

UniProt ID(s): Q9U0N3

PDB ID(s): None

Isoelectric Point: 5.96

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006496 Conserved hypothetical protein CHP01609, Plasmodium spp
PFam PF09688 Conserved hypothetical protein CHP01609, Plasmodium spp
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
25850860 The Plasmodium falciparum exportome contains non-canonical PEXEL/HT proteins. Schulze J, Kwiatkowski M, ..., Pick C 10.1111/mmi.13024