About Gene List

PF3D7_0112900

Genome location: Pf3D7_01_v3:483,603..487,841(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0043657 host cell
Component GO:0044228 host cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.11 0.94
Trophozoite not expressed 0.02 0.99
Schizont expressed 0.02 0.99
Gametocyte not expressed 0.01 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0112900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.995 | MFS: -2.003 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0N2

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=16.59) with 7WM6 (Global RMSD=20.67)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532929

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 191

Non-coding: 186 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 188 | Molecular Weight (kDa): 21.897

UniProt ID(s): Q9U0N2

PDB ID(s): None

Isoelectric Point: 6.68

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12
29162636 Quantitative Proteomic Profiling Reveals Novel Plasmodium falciparum SurfaceAntigens and Possible Vaccine Candidates. Nilsson Bark SK, Ahmad R, ..., Marti M 10.1074/mcp.RA117.000076
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g