About Gene List

PF3D7_0113000 (GARP)

Genome location: Pf3D7_01_v3:487,239..490,901(-)

Genome classification: Core

Function and Localization

Product Description: glutamic acid-rich protein GARP

SignalP Peptide: MNVLFLSYNICILFFVVCTLNFSTKC

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044538 host cell periphery
Component GO:0044228 host cell surface
Function GO:0046789 host cell surface receptor binding
Process GO:0052553 modulation by symbiont of host immune response
Process GO:0012501 programmed cell death

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.98 0.42
Trophozoite expressed 2.55 0.22
Schizont expressed 0.45 0.78
Gametocyte not expressed 0.40 0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0113000

Resistome Missense Mutations: L260H

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 4 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.159 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0N1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533518

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 18 7 16
disruptive 140 150 58 116
missense 57 49 25 46

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 21 23 13 24
disruptive 206 249 97 184
missense 75 92 38 84

PlasmoDB Total SNPs: 322

Non-coding: 128 | Synonymous: 101 | Nonsynonymous: 93 | Stop Codon: 0

Protein Information

Protein Length: 673 | Molecular Weight (kDa): 79.795

UniProt ID(s): Q9GTW3, Q9U0N1

PDB ID(s): None

Isoelectric Point: 4.58

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
27777305 Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates NovelLocalization Sequences That Target the Periphery of the Host Erythrocyte. Davies HM, Thalassinos K, Osborne AR 10.1074/jbc.M116.761213
30545833 Human erythrocyte band 3 is a host receptor for Plasmodium falciparum glutamicacid-rich protein. Almukadi H, Schwake C, ..., Chishti AH 10.1182/blood-2018-07-865451
32427965 Anti-PfGARP activates programmed cell death of parasites and reduces severemalaria. Raj DK, Das Mohapatra A, ..., Kurtis JD 10.1038/s41586-020-2220-1
37574178 Highly efficient overexpression and purification of multisubunit tetheringcomplexes in Saccharomyces cerevisiae Ji Q, Zhang K, ..., Mei K 10.1016/j.pep.2023.106351
38105992 Single cell transcriptional changes across the blood stages of artemisininresistant K13(C580Y) mutant Plasmodium falciparum upon dihydroartemisininexposure Oduor CI, Cunningham C, ..., Bailey JA 10.1101/2023.12.06.570387