About Gene List

PF3D7_0113100 (SURF1.1)

Genome location: Pf3D7_01_v3:494,941..500,347(+)

Genome classification: Core

Function and Localization

Product Description: surface-associated interspersed protein 1.1 (SURFIN 1.1)

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface
Component GO:0044228 host cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite not expressed 0.10 0.95
Schizont not expressed 0.03 0.98
Gametocyte not expressed 0.20 0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0113100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.981 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0N0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134606

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 41 25 39
disruptive 106 152 90 207
missense 97 127 76 159

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 26 68 39 45
disruptive 143 302 142 265
missense 116 241 118 171

PlasmoDB Total SNPs: 369

Non-coding: 76 | Synonymous: 123 | Nonsynonymous: 165 | Stop Codon: 5

Protein Information

Protein Length: 1555 | Molecular Weight (kDa): 192.351

UniProt ID(s): A0A348FV56, A0A348FV59, A0A348FV69, Q9U0N0

PDB ID(s): None

Isoelectric Point: 5.13

Protein Domain Annotations:

Source Family ID Description
InterPro IPR024288 Schizont-infected cell agglutination, C-terminal domain
PFam PF12879 Schizont-infected cell agglutination, C-terminal domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
15939796 SURFIN is a polymorphic antigen expressed on Plasmodium falciparum merozoites andinfected erythrocytes. Winter G, Kawai S, ..., Wahlgren M 10.1084/jem.20041392