About Gene List

PF3D7_0113200

Genome location: Pf3D7_01_v3:500,888..503,795(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell
Component GO:0030430 host cell cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.20 0.91
Trophozoite expressed 1.13 0.44
Schizont expressed 0.45 0.72
Gametocyte expressed 0.19 0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0113200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.287 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: B9ZSJ1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_211555

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 22 10 25
disruptive 69 123 44 90
missense 44 90 33 66

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 37 25 35
disruptive 101 193 62 117
missense 60 140 50 85

PlasmoDB Total SNPs: 199

Non-coding: 94 | Synonymous: 44 | Nonsynonymous: 61 | Stop Codon: 0

Protein Information

Protein Length: 592 | Molecular Weight (kDa): 70.111

UniProt ID(s): B9ZSJ1

PDB ID(s): None

Isoelectric Point: 9.87

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
33774908 Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. Jonsdottir TK, Counihan NA, ..., Gilson PR 10.1111/cmi.13332