About Gene List

PF3D7_0113300

Genome location: Pf3D7_01_v3:504,339..507,459(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp1), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.76 0.66
Trophozoite expressed 0.16 0.91
Schizont expressed 0.09 0.95
Gametocyte not expressed 0.11 0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0113300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.952 | MFS: -2.159 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U0M8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112098

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 23 26 10 32
disruptive 89 125 51 119
missense 49 90 41 85

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 27 45 18 37
disruptive 120 205 62 158
missense 67 147 50 94

PlasmoDB Total SNPs: 209

Non-coding: 91 | Synonymous: 44 | Nonsynonymous: 74 | Stop Codon: 0

Protein Information

Protein Length: 584 | Molecular Weight (kDa): 70.985

UniProt ID(s): Q9U0M8

PDB ID(s): None

Isoelectric Point: 7.98

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12