PF3D7_0113800

Genome location: Pf3D7_01_v3:526,530..536,562(+)

Genome classification: Core

Function and Localization

Product Description: DBL containing protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.21	0.91
Trophozoite	not expressed	0.11	0.95
Schizont	possibly expressed	0.26	0.89
Gametocyte	not expressed	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0113800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.076 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	110	108	51	129
disruptive	462	502	239	602
missense	336	382	183	456

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	132	185	64	145
disruptive	582	939	354	710
missense	403	719	266	391

PlasmoDB Total SNPs: 1277

Non-coding: 262 | Synonymous: 264 | Nonsynonymous: 742 | Stop Codon: 9

Protein Information

Protein Length: 2900 | Molecular Weight (kDa): 346.566

UniProt ID(s): A0A159SJ85, A0A159SK04, A0A159SKC3, A0A5P0ZZX3, A0A5P1A081, A0A5P1A0L6, A0A5P1A0N7, A0A5P1A1F3, A0A5P1A2U2, Q8I2E0, Q9U4X0

PDB ID(s): None

Isoelectric Point: 5.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008602	Duffy-antigen binding
PFam	PF05424	Duffy-antigen binding
Superfamily	SSF140924	N/A