Product Description: CX3CL1-binding protein 1
SignalP Peptide: MNIYIRTIFFAPFICLLIFSSNHG
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0030430 | host cell cytoplasm |
| Component | GO:0044228 | host cell surface |
| Function | GO:0019956 | chemokine binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0020035 | cytoadherence to microvasculature, mediated by symbiont protein |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.09 | 0.95 |
| Trophozoite | expressed | 0.02 | 0.99 |
| Schizont | expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.01 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0113900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.256 | MFS: -2.691 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2D9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 12 | 5 | 15 |
| disruptive | 5 | 25 | 8 | 30 |
| missense | 5 | 24 | 6 | 27 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 18 | 8 | 19 |
| disruptive | 14 | 47 | 31 | 55 |
| missense | 11 | 38 | 25 | 32 |
PlasmoDB Total SNPs: 110
Non-coding: 92 | Synonymous: 8 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 243 | Molecular Weight (kDa): 28.234
UniProt ID(s): Q8I2D9
PDB ID(s): None
Isoelectric Point: 9.17
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 20332084 | Protein export marks the early phase of gametocytogenesis of the human malariaparasite Plasmodium falciparum. | Silvestrini F, Lasonder E, ..., Alano P | 10.1074/mcp.M900479-MCP200 |
| 27653778 | Plasmodium falciparum proteins involved in cytoadherence of infected erythrocytesto chemokine CX3CL1. | Hermand P, Ciceron L, ..., Deterre P | 10.1038/srep33786 |
| 31851913 | Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparumGametocytogenesis and Transmission to Mosquitoes. | Jennison C, Lucantoni L, ..., Boddey JA | 10.1016/j.celrep.2019.11.073 |
| 32184257 | Role of Plasmodium falciparum Protein G EXP07 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum E MP1 Trafficking | McHugh E, Carmo OMS, ..., Dixon MWA | 10.1128/mBio.03320-19 |
| 38320620 | Combining single-molecule and expansion microscopy in fission yeast to visualizeprotein structures at the nanostructural level | Vojnovic I, Caspari OD, Hoskan MA, Endesfelder U | 10.1098/rsob.230414 |
| 36748990 | A high-quality reference genome for the fission yeast Schizosaccharomycesosmophilus | Jia GS, Zhang WC, ..., Du LL | 10.1093/g3journal/jkad028 |