Product Description: exported protein family 1
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.11 | 0.95 |
| Trophozoite | not expressed | 0.14 | 0.93 |
| Schizont | not expressed | 0.20 | 0.90 |
| Gametocyte | not expressed | 1.21 | 0.51 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0114000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.456 | #Insertions: 4
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: B9ZSJ2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 38 | 18 | 32 |
| disruptive | 61 | 134 | 61 | 133 |
| missense | 34 | 90 | 42 | 85 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 53 | 18 | 38 |
| disruptive | 86 | 245 | 76 | 154 |
| missense | 50 | 154 | 51 | 84 |
PlasmoDB Total SNPs: 785
Non-coding: 73 | Synonymous: 353 | Nonsynonymous: 359 | Stop Codon: 0
Protein Length: 1463 | Molecular Weight (kDa): 170.981
UniProt ID(s): B9ZSJ2
PDB ID(s): None
Isoelectric Point: 3.99
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001623 | DnaJ domain |
| InterPro | IPR026894 | DNAJ-containing protein, X-domain |
| InterPro | IPR036869 | Chaperone J-domain superfamily |
| PFam | PF00226 | DnaJ domain |
| PFam | PF14308 | DNAJ-containing protein, X-domain |
| Superfamily | SSF46565 | Chaperone J-domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 21908595 | An erythrocyte cytoskeleton-binding motif in exported Plasmodium falciparumproteins. | Kilili GK, LaCount DJ | 10.1128/EC.05180-11 |
| 23517413 | Novel Plasmodium falciparum Maurer's clefts protein families implicated in therelease of infectious merozoites. | Mbengue A, Audiger N, ..., Braun-Breton C | 10.1111/mmi.12193 |
| 31937828 | Investigating a Plasmodium falciparum erythrocyte invasion phenotype switch atthe whole transcriptome level | Nyarko PB, Tarr SJ, ..., Awandare GA | 10.1038/s41598-019-56386-y |