Product Description: Pfmc-2TM Maurer's cleft two transmembrane protein
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
| Component | GO:0020005 | symbiont-containing vacuole membrane |
| Process | GO:0042000 | translocation of peptides or proteins into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | possibly expressed | 0.10 | 0.96 |
| Schizont | possibly expressed | 0.01 | 0.99 |
| Gametocyte | not expressed | 0.01 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0114100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.315 | #Insertions: 6
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: B9ZSJ3
"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=13.12) with 3TD7 (Global RMSD=22.28)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 5 | 8 | 1 | 3 |
| missense | 4 | 5 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 1 |
| disruptive | 14 | 7 | 1 | 3 |
| missense | 9 | 4 | 0 | 0 |
PlasmoDB Total SNPs: 228
Non-coding: 56 | Synonymous: 79 | Nonsynonymous: 83 | Stop Codon: 10
Protein Length: 229 | Molecular Weight (kDa): 26.9
UniProt ID(s): B9ZSJ3
PDB ID(s): None
Isoelectric Point: 10.28
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15140830 | A Plasmodium gene family encoding Maurer's cleft membrane proteins: structuralproperties and expression profiling. | Sam-Yellowe TY, Florens L, ..., Yates JR 3rd | 10.1101/gr.2126104 |
| 15671043 | Proteomic analysis identifies novel proteins of the Maurer's clefts, a secretorycompartment delivering Plasmodium falciparum proteins to the surface of its hostcell. | Vincensini L, Richert S, ..., Braun Breton C | 10.1074/mcp.M400176-MCP200 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33916455 | Trafficking and Association of Plasmodium falciparum MC-2TM with the Maurer'sClefts | Yadavalli R, Peterson JW, Drazba JA, Sam-Yellowe TY | 10.3390/pathogens10040431 |