About Gene List

PF3D7_0114200 (EPF3)

Genome location: Pf3D7_01_v3:550,576..551,713(-)

Genome classification: Core

Function and Localization

Product Description: exported protein family 3

SignalP Peptide: MKHLLSLFKVSLFFLLIFKYSYK

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.00 1.00
Trophozoite not expressed 0.01 0.99
Schizont not expressed 0.00 1.00
Gametocyte not expressed 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0114200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.199 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2D6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_128718

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 6 5 12
disruptive 30 91 34 81
missense 12 49 19 45

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 16 6 10
disruptive 49 156 44 80
missense 19 84 23 37

PlasmoDB Total SNPs: 188

Non-coding: 12 | Synonymous: 75 | Nonsynonymous: 94 | Stop Codon: 7

Protein Information

Protein Length: 347 | Molecular Weight (kDa): 40.825

UniProt ID(s): Q8I2D6

PDB ID(s): None

Isoelectric Point: 6.71

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006410 Conserved hypothetical protein CHP01519, Plasmodium falciparum (isolate 3D7)
PFam PF09715 Conserved hypothetical protein CHP01519, Plasmodium falciparum (isolate 3D7)
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
23517413 Novel Plasmodium falciparum Maurer's clefts protein families implicated in therelease of infectious merozoites. Mbengue A, Audiger N, ..., Braun-Breton C 10.1111/mmi.12193