About Gene List

PF3D7_0114500

Genome location: Pf3D7_01_v3:557,700..558,946(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp10), unknown function

SignalP Peptide: MSFYYFKLSFISILLCILIITHK

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.07 0.98
Trophozoite expressed 0.17 0.93
Schizont expressed 0.09 0.95
Gametocyte not expressed 0.01 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0114500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.184 | MFS: -1.528 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2D5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215314

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 1 3 2
disruptive 42 12 4 16
missense 27 8 3 12

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 3 4 5
disruptive 44 24 5 31
missense 29 14 4 20

PlasmoDB Total SNPs: 101

Non-coding: 71 | Synonymous: 1 | Nonsynonymous: 25 | Stop Codon: 4

Protein Information

Protein Length: 110 | Molecular Weight (kDa): 12.845

UniProt ID(s): Q8I2D5

PDB ID(s): None

Isoelectric Point: 10.44

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12