About Gene List

PF3D7_0114700 (RIF)

Genome location: Pf3D7_01_v3:563,703..564,842(-)

Genome classification: Core

Function and Localization

Product Description: rifin

SignalP Peptide: MKLHYSKILLFLIPLNTLVTSSS

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020002 host cell plasma membrane
Process GO:0020033 antigenic variation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.00 1.00
Trophozoite possibly expressed 0.00 1.00
Schizont possibly expressed nd 1.00
Gametocyte possibly expressed 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0114700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.987 | MFS: -2.356 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2D4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100719

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 24 8 10
disruptive 41 67 23 57
missense 30 58 18 47

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 39 2 11
disruptive 63 110 36 63
missense 49 95 21 28

PlasmoDB Total SNPs: 144

Non-coding: 16 | Synonymous: 86 | Nonsynonymous: 38 | Stop Codon: 4

Protein Information

Protein Length: 323 | Molecular Weight (kDa): 35.804

UniProt ID(s): Q2XRF8, Q8I2D4

PDB ID(s): None

Isoelectric Point: 9.73

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006373 Variant surface antigen Rifin
PFam PF02009 Variant surface antigen Rifin
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10430943 Rifins: a second family of clonally variant proteins expressed on the surface ofred cells infected with Plasmodium falciparum. Kyes SA, Rowe JA, Kriek N, Newbold CI 10.1073/pnas.96.16.9333
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094