PF3D7_0115000 (SURF1.3)

Genome location: Pf3D7_01_v3:577,704..583,789(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: surface-associated interspersed protein 1.3 (SURFIN 1.3)

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0115000

Resistome Missense Mutations: I497L, K1549Q

Resistome Compounds with Missense Mutations: BCH070, Suloctidil

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.039 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2D1

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=0.09) with 1GWV (Global RMSD=21.18)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134606

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 564

Non-coding: 58 | Synonymous: 267 | Nonsynonymous: 237 | Stop Codon: 2

Protein Information

Protein Length: 1925 | Molecular Weight (kDa): 234.773

UniProt ID(s): A0A1Y1CDG2, A0A1Y1CDG9, A0A1Y1CDI3, A0A1Y1CDJ5, A0A1Y1CGH9, A0A348FV66, A0A348FV71, Q8I2D1

PDB ID(s): None

Isoelectric Point: 5.31

Protein Domain Annotations: