PF3D7_0200300

Genome location: Pf3D7_02_v3:35,927..37,249(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: erythrocyte membrane protein 1 (PfEMP1), exon 2

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0200300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.864 | MFS: -2.259 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96110

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 344

Non-coding: 0 | Synonymous: 154 | Nonsynonymous: 183 | Stop Codon: 7

Protein Information

Protein Length: 440 | Molecular Weight (kDa): 52.413

UniProt ID(s): A0A5P1A196, A0A5P1A2I0, O96110

PDB ID(s): None

Isoelectric Point: 4.84

Protein Domain Annotations: