About Gene List

PF3D7_0200600 (RIF)

Genome location: Pf3D7_02_v3:45,286..46,558(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: rifin

SignalP Peptide: MKLYYSKILLFSLILNILVPSSYA

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0020002 host cell plasma membrane
Component GO:0020003 symbiont-containing vacuole
Process GO:0020033 antigenic variation
Process GO:0020035 cytoadherence to microvasculature, mediated by symbiont protein
Process GO:0020013 modulation by symbiont of host erythrocyte aggregation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.00 1.00
Trophozoite possibly expressed 0.00 1.00
Schizont not expressed 0.00 1.00
Gametocyte not expressed 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0200600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.408 | MFS: -2.486 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96113

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100719

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 627

Non-coding: 71 | Synonymous: 110 | Nonsynonymous: 440 | Stop Codon: 6

Protein Information

Protein Length: 375 | Molecular Weight (kDa): 41.268

UniProt ID(s): O96113, Q2XRC3

PDB ID(s): None

Isoelectric Point: 8.51

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006373 Variant surface antigen Rifin
PFam PF02009 Variant surface antigen Rifin
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
10430943 Rifins: a second family of clonally variant proteins expressed on the surface ofred cells infected with Plasmodium falciparum. Kyes SA, Rowe JA, Kriek N, Newbold CI 10.1073/pnas.96.16.9333
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
25751816 RIFINs are adhesins implicated in severe Plasmodium falciparum malaria. Goel S, Palmkvist M, ..., Wahlgren M 10.1038/nm.3812