Genome location: Pf3D7_02_v3:48,923..50,147(-)
Genome classification: SubtelomericHypervariable
Product Description: rifin
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0020036 | Maurer's cleft |
Component | GO:0020002 | host cell plasma membrane |
Component | GO:0020003 | symbiont-containing vacuole |
Process | GO:0020033 | antigenic variation |
Process | GO:0020035 | cytoadherence to microvasculature, mediated by symbiont protein |
Process | GO:0020013 | modulation by symbiont of host erythrocyte aggregation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | possibly expressed | 0.00 | 1.00 |
Trophozoite | expressed | 0.00 | 1.00 |
Schizont | not expressed | 0.00 | 1.00 |
Gametocyte | possibly expressed | 0.00 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0200700
Resistome Missense Mutations: I155N, I155F
Resistome Compounds with Missense Mutations: AN13762, AN13956
Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.243 | MFS: -2.818 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96114
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 434
Non-coding: 50 | Synonymous: 127 | Nonsynonymous: 257 | Stop Codon: 0
Protein Length: 330 | Molecular Weight (kDa): 37.139
UniProt ID(s): O96114
PDB ID(s): None
Isoelectric Point: 8.31
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR006373 | Variant surface antigen Rifin |
InterPro | IPR011992 | EF-hand domain pair |
PFam | PF02009 | Variant surface antigen Rifin |
Superfamily | SSF47473 | EF-hand domain pair |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
10430943 | Rifins: a second family of clonally variant proteins expressed on the surface ofred cells infected with Plasmodium falciparum. | Kyes SA, Rowe JA, Kriek N, Newbold CI | 10.1073/pnas.96.16.9333 |
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
25751816 | RIFINs are adhesins implicated in severe Plasmodium falciparum malaria. | Goel S, Palmkvist M, ..., Wahlgren M | 10.1038/nm.3812 |