About Gene List

PF3D7_0201400

Genome location: Pf3D7_02_v3:69,088..69,771(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: Plasmodium exported protein (hyp10), unknown function

SignalP Peptide: MSCNYIKLSLFSIVLCIFIITHKLC

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.01 1.00
Trophozoite not expressed 0.00 1.00
Schizont not expressed 0.00 1.00
Gametocyte not expressed 0.01 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0201400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.673 | MFS: -2.309 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96119

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215314

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 80

Non-coding: 67 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 156 | Molecular Weight (kDa): 18.734

UniProt ID(s): O96119

PDB ID(s): None

Isoelectric Point: 9.44

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12