Genome location: Pf3D7_02_v3:76,725..79,448(-)
Genome classification: SubtelomericHypervariable
Product Description: PHISTb domain-containing RESA-like protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0044164 | host cell cytosol |
| Component | GO:0044228 | host cell surface |
| Process | GO:0020035 | cytoadherence to microvasculature, mediated by symbiont protein |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.71 | 0.70 |
| Trophozoite | expressed | 0.59 | 0.71 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | not expressed | 0.06 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0201600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.037 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96121
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 178
Non-coding: 65 | Synonymous: 31 | Nonsynonymous: 81 | Stop Codon: 1
Protein Length: 485 | Molecular Weight (kDa): 58.589
UniProt ID(s): O96121
PDB ID(s): None
Isoelectric Point: 6.52
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR019111 | Plasmodium RESA, N-terminal |
| PFam | PF09687 | Plasmodium RESA, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 25106850 | A conserved domain targets exported PHISTb family proteins to the periphery ofPlasmodium infected erythrocytes. | Tarr SJ, Moon RW, Hardege I, Osborne AR | 10.1016/j.molbiopara.2014.07.011 |
| 25342752 | Targeted disruption of a ring-infected erythrocyte surface antigen (RESA)-likeexport protein gene in Plasmodium falciparum confers stable chondroitin 4-sulfatecytoadherence capacity. | Goel S, Muthusamy A, ..., Gowda DC | 10.1074/jbc.M114.615393 |
| 15336631 | Identification and characterization of the rlp1+, the novel Rad51 paralog in thefission yeast Schizosaccharomyces pombe | Khasanov FK, Salakhova AF, ..., Bashkirov VI | 10.1016/j.dnarep.2004.05.010 |
| 17385316 | [Cell phenotypes of a mutant in the gene encoding a Rad51 paralog in fissionyeast] | Sultanova AN, Salakhova AF, Bashkirov VI, Khasanov FK | https://pubmed.ncbi.nlm.nih.gov/17385316/ |
| 35600144 | Characterization of sulfated polysaccharide activity against virulent Plasmodiumfalciparum PHISTb/RLP1 protein | Mutisya JM, Mobegi VA, ..., Andagalu BM | 10.12688/f1000research.26756.2 |
| 33002536 | Extraction optimization, physicochemical properties and antioxidant andhypoglycemic activities of polysaccharides from roxburgh rose (Rosa roxburghiiTratt.) leaves | Wu H, Li M, ..., Shang H | 10.1016/j.ijbiomac.2020.09.198 |
| 23544509 | Hypolipidemic and antioxidant activities of polysaccharides from Rosae LaevigataeFructus in rats | Yu CH, Dai XY, ..., Ying HZ | 10.1016/j.carbpol.2013.01.006 |