About Gene List

PF3D7_0201700

Genome location: Pf3D7_02_v3:80,851..84,937(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 1.48 0.41
Trophozoite expressed 0.21 0.89
Schizont expressed 0.21 0.88
Gametocyte not expressed 0.10 0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0201700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.214 | MFS: -2.696 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96122

"Best" AlphaFill ligand hit: NXL (nxl104, bound form, Local RMSD=1.47) with 6O9S (Global RMSD=20.03)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_131931

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 186

Non-coding: 79 | Synonymous: 48 | Nonsynonymous: 59 | Stop Codon: 0

Protein Information

Protein Length: 900 | Molecular Weight (kDa): 105.901

UniProt ID(s): O96122

PDB ID(s): None

Isoelectric Point: 4.44

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001623 DnaJ domain
InterPro IPR019111 Plasmodium RESA, N-terminal
InterPro IPR026894 DNAJ-containing protein, X-domain
InterPro IPR036869 Chaperone J-domain superfamily
PFam PF00226 DnaJ domain
PFam PF09687 Plasmodium RESA, N-terminal
PFam PF14308 DNAJ-containing protein, X-domain
Superfamily SSF46565 Chaperone J-domain superfamily

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g