Genome location: Pf3D7_02_v3:90,205..100,157(-)
Genome classification: SubtelomericHypervariable
Product Description: erythrocyte membrane protein 3
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005737 | cytoplasm |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0036457 | keratohyalin granule |
| Component | GO:0005634 | nucleus |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.66 | 0.75 |
| Trophozoite | expressed | 1.32 | 0.42 |
| Schizont | expressed | 0.43 | 0.77 |
| Gametocyte | not expressed | 0.14 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0201900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.927 | #Insertions: 21
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96124
"Best" AlphaFill ligand hit: PLP (pyridoxal-5'-phosphate, Local RMSD=0.73) with 1O61 (Global RMSD=43.28)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 609
Non-coding: 47 | Synonymous: 460 | Nonsynonymous: 102 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 10856227 | Targeted mutagenesis of Plasmodium falciparum erythrocyte membrane protein 3(PfEMP3) disrupts cytoadherence of malaria-infected red blood cells. | Waterkeyn JG, Wickham ME, ..., Cowman AF | 10.1093/emboj/19.12.2813 |
| 11223132 | The Plasmodium falciparum knob-associated PfEMP3 antigen is also expressed atpre-erythrocytic stages and induces antibodies which inhibit sporozoite invasion. | Gruner AC, Brahimi K, ..., Druilhe P | 10.1016/s0166-6851(00)00373-x |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
| 16262789 | Trafficking determinants for PfEMP3 export and assembly under the Plasmodiumfalciparum-infected red blood cell membrane. | Knuepfer E, Rug M, ..., Cowman AF | 10.1111/j.1365-2958.2005.04895.x |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 17626011 | Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) destabilizeserythrocyte membrane skeleton. | Pei X, Guo X, ..., An X | 10.1074/jbc.M701612200 |
| 22970262 | An exported heat shock protein 40 associates with pathogenesis-related knobs inPlasmodium falciparum infected erythrocytes. | Acharya P, Chaubey S, Grover M, Tatu U | 10.1371/journal.pone.0044605 |
| 26214367 | Structural basis for plasmepsin V inhibition that blocks export of malariaproteins to human erythrocytes. | Hodder AN, Sleebs BE, ..., Cowman AF | 10.1038/nsmb.3061 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |