Product Description: EMP1-trafficking protein
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0030430 | host cell cytoplasm |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0016020 | membrane |
| Component | GO:0032991 | protein-containing complex |
| Function | GO:0044877 | protein-containing complex binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 1.11 | 0.52 |
| Trophozoite | possibly expressed | 0.12 | 0.93 |
| Schizont | expressed | 0.11 | 0.94 |
| Gametocyte | not expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0202200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.65 | MFS: -3.049 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I669
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 136
Non-coding: 120 | Synonymous: 9 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 290 | Molecular Weight (kDa): 33.742
UniProt ID(s): Q8I669
PDB ID(s): None
Isoelectric Point: 10.19
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18614010 | Exported proteins required for virulence and rigidity of Plasmodiumfalciparum-infected human erythrocytes. | Maier AG, Rug M, ..., Cowman AF | 10.1016/j.cell.2008.04.051 |
| 25139348 | Export of virulence proteins by malaria-infected erythrocytes involves remodelingof host actin cytoskeleton. | Rug M, Cyrklaff M, ..., Cowman AF | 10.1182/blood-2014-06-583054 |
| 35417070 | Neutrophils impose strong immune pressure against PfEMP1 variants implicated incerebral malaria. | Zelter T, Strahilevitz J, ..., Granot Z | 10.15252/embr.202153641 |
| 30417267 | Yeast two-hybrid screening identifies MPZ-1 and PTP-1 as candidate scaffoldingproteins of metabotropic glutamate receptors in Caenorhabditis elegans | Dillon J, Holden-Dye L, O'Connor V | 10.1007/s10158-018-0218-2 |
| 31289175 | Positional Dynamics and Glycosomal Recruitment of Developmental Regulators duringTrypanosome Differentiation | Szoor B, Simon DV, ..., Matthews KR | 10.1128/mBio.00875-19 |