Product Description: translation-enhancing factor
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0043657 | host cell |
| Component | GO:0030430 | host cell cytoplasm |
| Component | GO:0005886 | plasma membrane |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0043022 | ribosome binding |
| Process | GO:0006417 | regulation of translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.39 | 0.84 |
| Trophozoite | expressed | 0.71 | 0.64 |
| Schizont | expressed | 0.37 | 0.78 |
| Gametocyte | not expressed | 0.10 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0202400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.252 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96127
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 43 | 15 | 36 |
| disruptive | 61 | 249 | 100 | 230 |
| missense | 43 | 168 | 73 | 148 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 69 | 18 | 39 |
| disruptive | 117 | 419 | 174 | 320 |
| missense | 71 | 271 | 118 | 177 |
PlasmoDB Total SNPs: 453
Non-coding: 174 | Synonymous: 135 | Nonsynonymous: 131 | Stop Codon: 13
Protein Length: 1192 | Molecular Weight (kDa): 141.849
UniProt ID(s): O96127
PDB ID(s): None
Isoelectric Point: 4.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR015299 | Gamete antigen, Plasmodium species |
| InterPro | IPR036469 | Gametocyte protein Pfg27 superfamily |
| PFam | PF09216 | Gamete antigen, Plasmodium species |
| Superfamily | SSF89162 | Gametocyte protein Pfg27 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 28288121 | A genetic system to study Plasmodium falciparum protein function. | Birnbaum J, Flemming S, ..., Spielmann T | 10.1038/nmeth.4223 |
| 28481333 | Regulation of PfEMP1-VAR2CSA translation by a Plasmodium translation-enhancingfactor. | Chan S, Frasch A, ..., Wahlgren M | 10.1038/nmicrobiol.2017.68 |