About Gene List

PF3D7_0202600

Genome location: Pf3D7_02_v3:129,336..134,329(-)

Genome classification: Core

Function and Localization

Product Description: nucleic acid-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed nd nd
Trophozoite expressed nd nd
Schizont expressed nd nd
Gametocyte expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0202600.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.377 | MFS: -2.621 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZY32

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.34) with 3A4M (Global RMSD=29.47)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109478

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 46 24 58
disruptive 60 207 119 216
missense 41 171 108 185

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 19 76 35 71
disruptive 113 365 159 287
missense 77 302 137 211

PlasmoDB Total SNPs: 307

Non-coding: 72 | Synonymous: 81 | Nonsynonymous: 154 | Stop Codon: 0

Protein Information

Protein Length: 1341 | Molecular Weight (kDa): 158.802

UniProt ID(s): O96129

PDB ID(s): None

Isoelectric Point: 4.08

Protein Domain Annotations:

Source Family ID Description
InterPro IPR012340 Nucleic acid-binding, OB-fold
PFam N/A N/A
Superfamily SSF50249 Nucleic acid-binding, OB-fold

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104