About Gene List

PF3D7_0203000 (ROPE)

Genome location: Pf3D7_02_v3:141,269..148,515(-)

Genome classification: Core

Function and Localization

Product Description: repetitive organellar protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0016020 membrane
Component GO:0020008 rhoptry

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.18 0.92
Trophozoite not expressed 0.45 0.74
Schizont possibly expressed 1.23 0.45
Gametocyte not expressed 0.49 0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0203000

Resistome Missense Mutations: V1780I

Resistome Compounds with Missense Mutations: BRD73842

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.887 | #Insertions: 8

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1135900)

  • Relative Growth Rate: 1.00 ± 0.19
  • Confidence: 4.73

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0301000)

Modification: Disrupted | RMgm-1739

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96133

"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=0.61) with 3JQQ (Global RMSD=20.52)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112372

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 17 98 35 93
disruptive 77 298 148 317
missense 40 238 125 253

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 35 149 64 102
disruptive 143 543 222 391
missense 84 422 172 287

PlasmoDB Total SNPs: 401

Non-coding: 149 | Synonymous: 141 | Nonsynonymous: 111 | Stop Codon: 0

Protein Information

Protein Length: 1979 | Molecular Weight (kDa): 237.747

UniProt ID(s): A0A144A0C5, O96133

PDB ID(s): None

Isoelectric Point: 5.82

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily SSF90257 N/A

Associated Publications

PMID Title Authors DOI/Link
9747969 A Plasmodium chabaudi protein contains a repetitive region with a predictedspectrin-like structure. Werner EB, Taylor WR, Holder AA 10.1016/s0166-6851(98)00067-x
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104