Product Description: protein kinase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.11.1 (Non-specific serine/threonine protein kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0004674 | protein serine/threonine kinase activity |
| Process | GO:0006468 | protein phosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.28 | 0.88 |
| Trophozoite | possibly expressed | 0.25 | 0.86 |
| Schizont | expressed | 1.39 | 0.50 |
| Gametocyte | expressed | 0.95 | 0.52 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0203100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.603 | #Insertions: 14
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96134
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.17) with 3Q4Z (Global RMSD=3.78)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATPKClDTTP53DRBEDTATBCAKN-93K252aCKI-7LAALSTAACS... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100860
Most Similar Human Ortholog: C9JCC0
TM-align score: 0.93 | RMSD: 1.42
Seq Identity: 0.38 | Length: 161 / 2485
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000102572 | serine/threonine kinase 24 |
| ENSG00000115694 | serine/threonine kinase 25 |
| ENSG00000134602 | serine/threonine kinase 26 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 35 | 109 | 71 | 134 |
| disruptive | 129 | 448 | 213 | 469 |
| missense | 69 | 358 | 178 | 376 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 51 | 213 | 81 | 151 |
| disruptive | 244 | 796 | 307 | 571 |
| missense | 136 | 626 | 261 | 400 |
PlasmoDB Total SNPs: 469
Non-coding: 94 | Synonymous: 209 | Nonsynonymous: 163 | Stop Codon: 3
Protein Length: 2485 | Molecular Weight (kDa): 293.768
UniProt ID(s): O96134
PDB ID(s): None
Isoelectric Point: 7.2
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000719 | Protein kinase domain |
| InterPro | IPR008271 | Serine/threonine-protein kinase, active site |
| InterPro | IPR011009 | Protein kinase-like domain superfamily |
| PFam | PF00069 | Protein kinase domain |
| Superfamily | SSF56112 | Protein kinase-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |