About Gene List

PF3D7_0203200

Genome location: Pf3D7_02_v3:157,937..159,891(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.49 0.78
Trophozoite possibly expressed 0.37 0.79
Schizont expressed 0.23 0.85
Gametocyte expressed 0.76 0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0203200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.971 | MFS: -2.198 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3A8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532384

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 15 14 29
disruptive 12 68 39 99
missense 7 64 37 81

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 38 18 24
disruptive 24 158 66 112
missense 16 129 55 83

PlasmoDB Total SNPs: 127

Non-coding: 48 | Synonymous: 38 | Nonsynonymous: 41 | Stop Codon: 0

Protein Information

Protein Length: 507 | Molecular Weight (kDa): 59.788

UniProt ID(s): C6S3A8

PDB ID(s): None

Isoelectric Point: 7.39

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097