Product Description: ERCC1 nucleotide excision repair protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.21.1 (Deoxyribonuclease I)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070522 | ERCC4-ERCC1 complex |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0000110 | nucleotide-excision repair factor 1 complex |
| Function | GO:0003684 | damaged DNA binding |
| Function | GO:0004520 | endodeoxyribonuclease activity |
| Function | GO:0003697 | single-stranded DNA binding |
| Process | GO:0070914 | UV-damage excision repair |
| Process | GO:0000710 | meiotic mismatch repair |
| Process | GO:0006312 | mitotic recombination |
| Process | GO:0006289 | nucleotide-excision repair |
| Process | GO:0006296 | nucleotide-excision repair, DNA incision, 5'-to lesion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.09 | 0.96 |
| Trophozoite | expressed | 0.33 | 0.79 |
| Schizont | possibly expressed | 0.25 | 0.84 |
| Gametocyte | expressed | 0.70 | 0.61 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0203300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.156 | MFS: -3.229 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96136
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.21.1 | deoxyribonuclease I | KClSDSDTTRNAEDTAEGTAactin3'-AMP5'-GMPHPO42-P2O74-5'-GTP... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102832
Most Similar Human Ortholog: K7ES46
TM-align score: 0.56 | RMSD: 2.45
Seq Identity: 0.33 | Length: 127 / 242
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000012061 | ERCC excision repair 1, endonuclease non-catalytic subunit |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 15 | 6 | 12 |
| disruptive | 6 | 14 | 11 | 27 |
| missense | 2 | 14 | 11 | 25 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 21 | 18 | 5 |
| disruptive | 13 | 51 | 28 | 53 |
| missense | 4 | 37 | 26 | 39 |
PlasmoDB Total SNPs: 104
Non-coding: 91 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 242 | Molecular Weight (kDa): 28.288
UniProt ID(s): O96136
PDB ID(s): None
Isoelectric Point: 9.18
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004579 | ERCC1/RAD10/SWI10 family |
| InterPro | IPR010994 | RuvA domain 2-like |
| InterPro | IPR011335 | Restriction endonuclease type II-like |
| PFam | PF03834 | ERCC1/RAD10/SWI10 family |
| Superfamily | SSF47781 | RuvA domain 2-like |
| Superfamily | SSF52980 | Restriction endonuclease type II-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 38279246 | Unveiling Novel ERCC1-XPF Complex Inhibitors: Bridging the Gap from In Silico Exploration to Experimental Design | Manguinhas R, Serra PA, ..., Guedes RC | 10.3390/ijms25021246 |
| 38300970 | Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-ProteinInteraction | Obermann R, Yemane B, ..., Janetka JW | 10.1002/cmdc.202300648 |
| 38260495 | Multiple DNA repair pathways prevent acetaldehyde-induced mutagenesis in yeast | Porcher L, Vijayraghavan S, ..., Saini N | 10.1101/2024.01.07.574575 |
| 38272916 | ERCC1 abundance is an indicator of DNA repair-apoptosis decision upon DNA damage | Erdemir Sayan S, Sreekumar R, ..., Sayan AE | 10.1038/s41420-024-01817-7 |