Product Description: WD repeat-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | not expressed | 0.11 | 0.93 |
| Schizont | not expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.55 | 0.70 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0203800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.195 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I666
"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=10.38) with 4GTW (Global RMSD=17.18)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 39 | 13 | 36 |
| disruptive | 1 | 17 | 17 | 29 |
| missense | 1 | 17 | 15 | 25 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 63 | 24 | 31 |
| disruptive | 3 | 45 | 52 | 98 |
| missense | 3 | 35 | 41 | 69 |
PlasmoDB Total SNPs: 234
Non-coding: 215 | Synonymous: 16 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 542 | Molecular Weight (kDa): 63.492
UniProt ID(s): Q8I666
PDB ID(s): None
Isoelectric Point: 9.08
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |