Product Description: condensin-2 complex subunit H2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000793 | condensed chromosome |
| Component | GO:0000796 | condensin complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003682 | chromatin binding |
| Process | GO:0051276 | chromosome organization |
| Process | GO:0010032 | meiotic chromosome condensation |
| Process | GO:0051306 | mitotic sister chromatid separation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.19 | 0.88 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | expressed | 0.44 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0204000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.227 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0301800)
Modification: Disrupted | RMgm-1745
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96140
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 43 | 28 | 50 |
| disruptive | 12 | 88 | 56 | 104 |
| missense | 11 | 86 | 51 | 101 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 80 | 40 | 58 |
| disruptive | 34 | 182 | 84 | 149 |
| missense | 23 | 157 | 75 | 116 |
PlasmoDB Total SNPs: 127
Non-coding: 71 | Synonymous: 39 | Nonsynonymous: 17 | Stop Codon: 0
Protein Length: 797 | Molecular Weight (kDa): 95.933
UniProt ID(s): O96140
PDB ID(s): None
Isoelectric Point: 6.11
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009378 | Condensin II complex subunit H2, N-terminal |
| InterPro | IPR031739 | Condensin-2 complex subunit H2 |
| PFam | PF06278 | Condensin II complex subunit H2, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 32049018 | Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and AreEssential for Parasite Proliferation and Transmission. | Pandey R, Abel S, ..., Tewari R | 10.1016/j.celrep.2020.01.033 |
| 25723539 | Drosophila casein kinase I alpha regulates homolog pairing and genomeorganization by modulating condensin II subunit Cap-H2 levels | Nguyen HQ, Nye J, ..., Bosco G | 10.1371/journal.pgen.1005014 |
| 31270536 | Recurrent Losses and Rapid Evolution of the Condensin II Complex in Insects | King TD, Leonard CJ, ..., Phadnis N | 10.1093/molbev/msz140 |
| 34669718 | Bivalent individualization during chromosome territory formation in Drosophilaspermatocytes by controlled condensin II protein activity and additional forcegenerators | Vernizzi L, Lehner CF | 10.1371/journal.pgen.1009870 |
| 35983835 | Molecular dissection of condensin II-mediated chromosome assembly using in vitroassays | Yoshida MM, Kinoshita K, ..., Hirano T | 10.7554/eLife.78984 |
| 25758823 | Condensin II Regulates Interphase Chromatin Organization Through the Mrg-BindingMotif of Cap-H2 | Wallace HA, Klebba JE, ..., Bosco G | 10.1534/g3.115.016634 |