About Gene List

PF3D7_0204100

Genome location: Pf3D7_02_v3:181,749..189,877(-)

Genome classification: Core

Function and Localization

Product Description: Sel1 repeat-containing protein, putative

SignalP Peptide: MIKNVFYLNFIFSFFLLIIKC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005829 cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.23 0.89
Trophozoite not expressed 0.99 0.54
Schizont not expressed 1.98 0.30
Gametocyte not expressed 1.18 0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0204100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.146 | MFS: -2.863 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9TY98

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533193

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 106 68 144
disruptive 126 289 134 351
missense 53 212 123 300

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 30 217 94 123
disruptive 197 540 210 471
missense 83 425 169 336

PlasmoDB Total SNPs: 350

Non-coding: 81 | Synonymous: 109 | Nonsynonymous: 160 | Stop Codon: 0

Protein Information

Protein Length: 2295 | Molecular Weight (kDa): 271.49

UniProt ID(s): Q25776, Q9TY98

PDB ID(s): None

Isoelectric Point: 8.57

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006597 Sel1-like repeat
InterPro IPR011004 Trimeric LpxA-like superfamily
PFam PF08238 Sel1-like repeat
Superfamily SSF51161 Trimeric LpxA-like superfamily
Superfamily SSF81901

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
24841368 Identifying novel cell cycle proteins in Apicomplexa parasites throughco-expression decision analysis. Butler CL, Lucas O, ..., White M 10.1371/journal.pone.0097625