About Gene List

PF3D7_0204300

Genome location: Pf3D7_02_v3:194,272..197,151(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.19 0.90
Trophozoite not expressed 0.30 0.81
Schizont not expressed 0.08 0.95
Gametocyte not expressed 0.37 0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0204300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.318 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0302100)

  • Relative Growth Rate: 1.00 ± 0.07
  • Confidence: 6.60

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0302100)

Modification: Disrupted | RMgm-1747

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96141

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533139

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 41 29 51
disruptive 16 142 96 159
missense 14 137 93 149

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 18 87 39 51
disruptive 46 298 141 238
missense 39 260 125 176

PlasmoDB Total SNPs: 103

Non-coding: 42 | Synonymous: 31 | Nonsynonymous: 30 | Stop Codon: 0

Protein Information

Protein Length: 696 | Molecular Weight (kDa): 83.822

UniProt ID(s): O96141

PDB ID(s): None

Isoelectric Point: 8.7

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104