Product Description: dynein light chain, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030286 | dynein complex |
| Function | GO:0045505 | dynein intermediate chain binding |
| Function | GO:0051959 | dynein light intermediate chain binding |
| Process | GO:2000582 | obsolete positive regulation of microtubule motor activity, plus-end-directed |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.01 | 1.00 |
| Trophozoite | no data | 0.02 | 0.99 |
| Schizont | no data | 0.00 | 1.00 |
| Gametocyte | no data | 0.07 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0204400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.987 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3A9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105070
Most Similar Human Ortholog: O96015
TM-align score: 0.86 | RMSD: 1.43
Seq Identity: 0.34 | Length: 100 / 107
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100246 | dynein axonemal light chain 4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 6 | 4 | 10 |
| disruptive | 1 | 3 | 3 | 12 |
| missense | 1 | 3 | 3 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 14 | 10 | 6 |
| disruptive | 3 | 9 | 7 | 18 |
| missense | 3 | 8 | 6 | 15 |
PlasmoDB Total SNPs: 19
Non-coding: 14 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 107 | Molecular Weight (kDa): 12.253
UniProt ID(s): C6S3A9
PDB ID(s): None
Isoelectric Point: 7.7
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001372 | Dynein light chain, type 1/2 |
| InterPro | IPR037177 | Dynein light chain superfamily |
| PFam | PF01221 | Dynein light chain, type 1/2 |
| Superfamily | SSF54648 | Dynein light chain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |