Product Description: hexose transporter
SignalP Peptide: N/A
# Transmembrane Domains: 12
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0009986 | cell surface |
Component | GO:0020020 | food vacuole |
Component | GO:0005887 | integral component of plasma membrane |
Component | GO:0005634 | nucleus |
Component | GO:0005886 | plasma membrane |
Function | GO:0055056 | D-glucose transmembrane transporter activity |
Function | GO:0005353 | fructose transmembrane transporter activity |
Function | GO:0005355 | glucose transmembrane transporter activity |
Function | GO:0015149 | hexose transmembrane transporter activity |
Process | GO:0015755 | fructose transmembrane transport |
Process | GO:1904659 | glucose transmembrane transport |
Process | GO:0008645 | hexose transmembrane transport |
Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.24 | 0.88 |
Trophozoite | expressed | 0.31 | 0.81 |
Schizont | expressed | 0.20 | 0.86 |
Gametocyte | expressed | 0.40 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0204700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.294 | MFS: -2.474 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0302500)
Modification: Tagged | RMgm-1106
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q7KWJ5
"Best" AlphaFill ligand hit: 37X (octyl glucose neopentyl glycol, Local RMSD=0.36) with 5C65 (Global RMSD=4.76)
No associated EC numbersOrthology to BindingDB Entries:
UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
---|---|---|---|---|
P11166 | Solute carrier family 2, facilitated glucose transporter member 1 | HOGENOM, OMA | PUG-1US10729691, Example 1US10729691, Example 2US10729691, Example 3... | |
P19357 | Solute carrier family 2, facilitated glucose transporter member 4 | HOGENOM | CHEMBL4171968CHEMBL4576794CHEMBL4550275CHEMBL4439282... | |
P11167 | Solute carrier family 2, facilitated glucose transporter member 1 | Rattus norvegicus | HOGENOM, OMA | CHEMBL522813 |
P14672 | Solute carrier family 2, facilitated glucose transporter member 4 | HOGENOM | CHEMBL4171968CHEMBL4793560 | |
P11169 | Solute carrier family 2, facilitated glucose transporter member 3 | HOGENOM | CHEMBL3780717CHEMBL3780534CHEMBL3781994CHEMBL3781827... | |
P11168 | Solute carrier family 2, facilitated glucose transporter member 2 | Homo sapiens | HOGENOM | CHEMBL3780235CHEMBL3781347CHEMBL3781548CHEMBL3781384... |
O97467 | Putative sugar transporter | Plasmodium falciparum | OMA, OrthoMCL, OrthoMCL BLAST | US10729691, Example 1US10729691, Example 2US10729691, Example 3US10729691, Example 4... |
Ortholog Group (OrthoMCL): OG6_100060
Most Similar Human Ortholog: A0A6Q8PFI8
TM-align score: 0.90 | RMSD: 2.40
Seq Identity: 0.27 | Length: 350 / 504
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000059804 | solute carrier family 2 member 3 |
ENSG00000117394 | solute carrier family 2 member 1 |
ENSG00000136856 | solute carrier family 2 member 8 |
ENSG00000142583 | solute carrier family 2 member 5 |
ENSG00000160326 | solute carrier family 2 member 6 |
ENSG00000163581 | solute carrier family 2 member 2 |
ENSG00000173262 | solute carrier family 2 member 14 |
ENSG00000181856 | solute carrier family 2 member 4 |
ENSG00000281165 | solute carrier family 2 member 6 |
ENSG00000288174 | solute carrier family 2 member 4 |
Protein Length: 504 | Molecular Weight (kDa): 56.417
PDB ID(s): None
Isoelectric Point: 8.75
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR003663 | Sugar/inositol transporter |
InterPro | IPR005828 | Major facilitator, sugar transporter-like |
InterPro | IPR005829 | Sugar transporter, conserved site |
InterPro | IPR036259 | MFS transporter superfamily |
PFam | PF00083 | Major facilitator, sugar transporter-like |
Superfamily | SSF103473 | MFS transporter superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 10 | 26 | 15 | 35 |
disruptive | 2 | 11 | 3 | 28 |
missense | 2 | 11 | 2 | 21 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 13 | 63 | 20 | 35 |
disruptive | 4 | 33 | 30 | 85 |
missense | 3 | 23 | 22 | 60 |
PlasmoDB Total SNPs: 138
Non-coding: 117 | Synonymous: 18 | Nonsynonymous: 3 | Stop Codon: 0
PMID | Title | Authors | DOI/Link |
---|---|---|---|
9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
10066789 | Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitativehexose transporter. | Woodrow CJ, Penny JI, Krishna S | 10.1074/jbc.274.11.7272 |
11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
12238947 | Comparative characterization of hexose transporters of Plasmodium knowlesi,Plasmodium yoelii and Toxoplasma gondii highlights functional differences withinthe apicomplexan family. | Joet T, Holterman L, ..., Krishna S | 10.1042/BJ20021189 |
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
20132450 | Life cycle studies of the hexose transporter of Plasmodium species and geneticvalidation of their essentiality. | Slavic K, Straschil U, ..., Krishna S | 10.1111/j.1365-2958.2010.07060.x |
21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
25894322 | Identification of Selective Inhibitors of the Plasmodium falciparum HexoseTransporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds. | Ortiz D, Guiguemde WA, ..., Landfear SM | 10.1371/journal.pone.0123598 |
26248369 | The Glucose Transporter PfHT1 Is an Antimalarial Target of the HIV ProteaseInhibitor Lopinavir. | Kraft TE, Armstrong C, ..., Hruz PW | 10.1128/AAC.00899-15 |
27128092 | Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. | Swearingen KE, Lindner SE, ..., Sinnis P | 10.1371/journal.ppat.1005606 |
30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
31071153 | Identification of druggable small molecule antagonists of the Plasmodiumfalciparum hexose transporter PfHT and assessment of ligand access to the glucosepermeation pathway via FLAG-mediated protein engineering. | Heitmeier MR, Hresko RC, ..., Hruz PW | 10.1371/journal.pone.0216457 |
31996846 | The molecular basis for sugar import in malaria parasites. | Qureshi AA, Suades A, ..., Drew D | 10.1038/s41586-020-1963-z |
38110471 | Characterization of a novel RNAi yeast insecticide that silences mosquito 5-HT1receptor genes | Mysore K, Njoroge TM, ..., Duman-Scheel M | 10.1038/s41598-023-49799-3 |
38282613 | Functional characterization of Plasmodium vivax hexose transporter 1 | Won JY, Mazigo E, Cha SH, Han JH | 10.3389/fcimb.2023.1321240 |