Product Description: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.1.1.163 (Demethylmenaquinone methyltransferase);2.1.1.201 (2-methoxy-6-polyprenyl-1,4-benzoquinol methylase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005759 | mitochondrial matrix |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0044310 | osmiophilic body |
| Function | GO:0043334 | 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity |
| Function | GO:0008168 | methyltransferase activity |
| Function | GO:0030580 | quinone cofactor methyltransferase activity |
| Process | GO:1901663 | quinone biosynthetic process |
| Process | GO:0006744 | ubiquinone biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | not expressed | 0.27 | 0.82 |
| Schizont | not expressed | 0.10 | 0.93 |
| Gametocyte | possibly expressed | 0.34 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0204900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.321 | MFS: -2.529 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0302700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96145
"Best" AlphaFill ligand hit: TAM (tris(hydroxyethyl)aminomethane, Local RMSD=0.17) with 4OBW (Global RMSD=8.60)
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101003
Most Similar Human Ortholog: F8VVX6
TM-align score: 0.86 | RMSD: 1.94
Seq Identity: 0.47 | Length: 197 / 354
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000110871 | coenzyme Q5, methyltransferase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 18 | 13 | 29 |
| disruptive | 3 | 22 | 25 | 47 |
| missense | 3 | 22 | 24 | 47 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 37 | 13 | 36 |
| disruptive | 6 | 59 | 34 | 74 |
| missense | 4 | 55 | 31 | 68 |
PlasmoDB Total SNPs: 107
Non-coding: 88 | Synonymous: 12 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 354 | Molecular Weight (kDa): 41.169
UniProt ID(s): O96145
PDB ID(s): None
Isoelectric Point: 9.01
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004033 | UbiE/COQ5 methyltransferase |
| InterPro | IPR023576 | UbiE/COQ5 methyltransferase, conserved site |
| InterPro | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase |
| PFam | PF01209 | UbiE/COQ5 methyltransferase |
| Superfamily | SSF53335 | S-adenosyl-L-methionine-dependent methyltransferase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 27432909 | Comparative Proteomics and Functional Analysis Reveal a Role of Plasmodiumfalciparum Osmiophilic Bodies in Malaria Parasite Transmission. | Suarez-Cortes P, Sharma V, ..., Alano P | 10.1074/mcp.M116.060681 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 29804512 | Suppression of respiratory growth defect of mutant deficient in mitochondrialphospholipase A(1) by overexpression of genes involved in coenzyme Q synthesis inSaccharomyces cerevisiae | Morisada S, Nishida I, ..., Fukuda R | 10.1080/09168451.2018.1476124 |