About Gene List

PF3D7_0205000

Genome location: Pf3D7_02_v3:212,672..214,714(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.98
Trophozoite possibly expressed 0.13 0.92
Schizont not expressed 0.05 0.97
Gametocyte expressed 0.83 0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0205000

Resistome Missense Mutations: N389K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.036 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96146

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532319

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 27 10 21
disruptive 18 93 47 89
missense 11 87 44 82

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 42 15 35
disruptive 41 155 63 113
missense 29 132 59 88

PlasmoDB Total SNPs: 186

Non-coding: 88 | Synonymous: 53 | Nonsynonymous: 44 | Stop Codon: 1

Protein Information

Protein Length: 508 | Molecular Weight (kDa): 61.323

UniProt ID(s): O96146

PDB ID(s): None

Isoelectric Point: 10.01

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097