PF3D7_0205100

Genome location: Pf3D7_02_v3:214,838..217,843(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.04	0.98
Trophozoite	expressed	0.17	0.91
Schizont	expressed	0.03	0.98
Gametocyte	expressed	1.22	0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0205100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.742 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3B0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532793

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	35	19	47
disruptive	27	127	77	141
missense	20	90	61	108

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	67	33	50
disruptive	71	227	124	163
missense	40	168	96	109

PlasmoDB Total SNPs: 283

Non-coding: 135 | Synonymous: 104 | Nonsynonymous: 44 | Stop Codon: 0

Protein Information

Protein Length: 705 | Molecular Weight (kDa): 86.237

UniProt ID(s): C6S3B0

PDB ID(s): None

Isoelectric Point: 8.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
9804551	Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Tettelin H, ..., Hoffman SL	10.1126/science.282.5391.1126
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097