Product Description: MORN repeat protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.00 | 1.00 |
| Trophozoite | expressed | 0.01 | 0.99 |
| Schizont | expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.15 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0205200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.971 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O96147
"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=0.64) with 4IJ8 (Global RMSD=15.01)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103378
Most Similar Human Ortholog: Q8WYR4
TM-align score: 0.86 | RMSD: 1.85
Seq Identity: 0.23 | Length: 183 / 196
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000160188 | radial spoke head component 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 13 | 7 | 12 |
| disruptive | 1 | 23 | 21 | 32 |
| missense | 1 | 22 | 20 | 28 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 22 | 12 | 13 |
| disruptive | 7 | 58 | 29 | 46 |
| missense | 5 | 49 | 26 | 35 |
PlasmoDB Total SNPs: 68
Non-coding: 57 | Synonymous: 4 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 196 | Molecular Weight (kDa): 23.379
UniProt ID(s): O96147
PDB ID(s): None
Isoelectric Point: 10.07
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003409 | MORN motif |
| PFam | PF02493 | MORN motif |
| Superfamily | SSF82185 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9804551 | Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Tettelin H, ..., Hoffman SL | 10.1126/science.282.5391.1126 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |