About Gene List

PF3D7_0205300

Genome location: Pf3D7_02_v3:219,690..222,256(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.01 0.99
Trophozoite not expressed 0.03 0.98
Schizont not expressed 0.03 0.98
Gametocyte expressed 0.45 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0205300

Resistome Missense Mutations: S315R

Resistome Compounds with Missense Mutations: MMV007224

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -1.296 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O96148

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.05) with 6JWR (Global RMSD=23.83)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533421

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 31 23 35
disruptive 31 119 58 135
missense 18 110 50 117

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 69 31 45
disruptive 55 257 103 159
missense 32 215 80 116

PlasmoDB Total SNPs: 191

Non-coding: 118 | Synonymous: 41 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 616 | Molecular Weight (kDa): 73.268

UniProt ID(s): O96148

PDB ID(s): None

Isoelectric Point: 10.21

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097